Selected publications

(for complete list of publications see below)


Walter, C., Marada, A., Suhm, T., Ernsberger, R., Muders, V., Kücükköse, C., Sánchez-Martín, P., Hu, Z., Aich, A., Loroch, S., Solari, F.A., Poveda-Huertes, D., Schwierzok, A., Pommerening, H., Matic, S., Brix, J., Sickmann, A., Kraft, C., Dengjel, J., Dennerlein, S., Brummer, T., Vögtle, F.N., and Meisinger, C. (2021). Global kinome profiling reveals DYRK1A as critical activator of the human mitochondrial import machinery. Nat. Commun. 12, 4284.


Poveda-Huertes, D., Matic, S., Marada, A., Habernig, L., Licheva, M., Myketin, L., Gilsbach, R., Tosal-Castano, S., Papinski, D., Mulica, P., Kretz, O., Kücükköse, C., Taskin, A.A., Hein, L., Kraft. C., Büttner, S., Meisinger, C.*, and Vögtle, F.N.* (2020). An early mtUPR: Redistribution of the nuclear transcription factor Rox1 into mitochondria protects against intramitochondrial proteotoxic aggregates. Mol. Cell 77, 180-188.


Vögtle, F.N., Burkhart, J.M., Gonczarowska-Jorge, H., Kücükköse, C., Taskin, A.A., Kopczynski, D., Ahrends, R., Mossmann, D., Sickmann, A., Zahedi, R.P., and Meisinger, C. (2017). Landscape of submitochondrial protein distribution. Nat. Commun. 8, 290.


Harbauer, A.B., Opalinska, M., Gerbeth, C., Herman, J.S., Rao, S., Schönfisch, B., Guiard, B., Schmidt, O., Pfanner, N., and Meisinger, C. (2014). Cell cycle-dependent regulation of mitochondrial preprotein translocase. Science 346, 1109-1113.


Mossmann, D., Vögtle, F.N., Taskin, A.A., Teixeira, P.F., Ring, J., Burkhart, J.M., Burger, N., Pinho, C.M., Tadic, J., Loreth, D., Graff, C., Metzger, F., Sickmann, A., Kretz, O., Wiedemann, N., Zahedi, R.P., Madeo, F., Glaser, E., and Meisinger, C. (2014). Amyloid-beta peptide induces mitochondrial dysfunction by inhibition of preprotein maturation. Cell Metab.  20, 662-669.


Gerbeth, C., Schmidt, O., Rao, S., Harbauer, A.B., Mikropoulou, D., Opalinska, M., Guiard, B., Pfanner, N., and Meisinger, C. (2013). Differential regulation of the central mitochondrial import receptor by cytosolic and organelle-bound kinases. Cell Metab. 18, 578-587.


Schmidt, O., Harbauer, A.B., Rao, S., Eyrich, B., Zahedi, R.P., Stojanovski, D., Schönfisch, B., Guiard, B., Sickmann, A., Pfanner, N., and Meisinger, C. (2011). Regulation of mitochondrial protein import by cytosolic kinases. Cell 144, 227-239.


Vögtle, F.N., Wortelkamp, S., Zahedi, R.P., Becker, D., Leidhold, C., Gevaert, K., Kellermann, J., Voos, W., Sickmann, A., Pfanner, N., and Meisinger, C. (2009). Global analysis of the mitochondrial N-Proteome identifies a processing peptidase critical for protein stability. Cell 139, 428-439.


Meisinger, C., Rissler,  M., Chacinska, A., Milenkovic, D., Kozjak, V., Schönfisch, B., Lohaus, C., Meyer, H.E., Yaffe, M.P., Guiard,  B., Wiedemann, N., and Pfanner, N. (2004). The mitochondrial morphology protein Mdm10 functions in assembly of the preprotein translocase of the outer membrane. Dev. Cell 7, 61-71.


Sickmann, A., Reinders, J., Wagner, Y., Joppich, C., Zahedi, R., Meyer, H.E., Schönfisch, B., Perschil, I., Chacinska, A., Guiard, B., Rehling, P., Pfanner, N. and Meisinger, C. (2003). The proteome of Saccharomyces cerevisiae mitochondria. Proc. Natl. Acad. Sci. USA 100, 13207-13212.


Wiedemann, N., Kozjak, V., Chacinska, A., Schönfisch, B., Rospert, S., Ryan, M.T., Pfanner, N., and Meisinger, C. (2003). Machinery for protein sorting and assembly in the mitochondrial outer membrane. Nature 424, 565-571.





All publications


Vögtle, F.N., Koch, H.G., and Meisinger, C. (2021). A common evolutionary origin reveals fundamental principles of protein insertases. PLoS Biol. 20, e3001558.


Walter, C., Marada, A.,  and Meisinger, C. (2021). Monitoring checkpoints of metabolism and protein biogenesis in mitochondria by Phos-tag technology. J. Proteomics 252, 104430.


Vögtle, F.N., and Meisinger, C. (2021). Mitochondria as emergency landing for abandoned peroxins. EMBO Rep. 22, e53790.


Walter, C., Marada, A., Suhm, T., Ernsberger, R., Muders, V., Kücükköse, C., Sánchez-Martín, P., Hu, Z., Aich, A., Loroch, S., Solari, F.A., Poveda-Huertes, D., Schwierzok, A., Pommerening, H., Matic, S., Brix, J., Sickmann, A., Kraft, C., Dengjel, J., Dennerlein, S., Brummer, T., Vögtle, F.N., and Meisinger, C. (2021). Global kinome profiling reveals DYRK1A as critical activator of the human mitochondrial import machinery. Nat. Commun. 12, 4284.


Poveda-Huertes, D., Matic, S., Marada, A., Habernig, L., Licheva, M., Myketin, L., Gilsbach, R., Tosal-Castano, S., Papinski, D., Mulica, P., Kretz, O., Kücükköse, C., Taskin, A.A., Hein, L., Kraft. C., Büttner, S., Meisinger, C.*, and Vögtle, F.N.* (2020). An early mtUPR: Redistribution of the nuclear transcription factor Rox1 into mitochondria protects against intramitochondrial proteotoxic aggregates. Mol. Cell 77, 180-188.


Makepeace, K.A.T., Mohammed, Y., Rudashevskaya, E.L., Petrotchenko, E.V., Vögtle, F.N., Meisinger, C., Sickmann, A., and Borchers, C.H. (2020). Improving Identification of In-organello Protein-Protein Interactions Using an Affinity-enrichable, Isotopically Coded, and Mass Spectrometry-cleavable Chemical Crosslinker. Mol. Cell. Proteomics 19, 624-639.


Niemi, N.M., Wilson, G.M., Overmyer, K.A., Vögtle, F.N., Myketin, L., Lohman, D.C., Schueler, K.L., Attie, A.D., Meisinger, C., Coon, J.J., and Pagliarini, D.J. (2019). Pptc7 is an essential phosphatase for promoting mammalian mitochondrial metabolism and biogenesis. Nat. Commun. 10, 3197.


Walther, C., Gonczarowska-Jorge, H., Sickmann, A., Zahedi, R.P., Meisinger, C.* and Schmidt, O.* (2018). Advanced tools for the analysis of protein phosphorylation in yeast mitochondria. Anal. Biochem. 554, 23-27.


Kravic, B., Harbauer, A.B., Romanello, V., Simeone, L., Vögtle, F.N., Kaiser, T., Straubinger, M., Huraskin, D., Böttcher, M., Cerqua, C., Martin, E.D., Poveda-Huertes, D., Buttgereit, A., Rabalski, A.J., Heuss, D., Rudolf, R., Friedrich, O., Litchfield, D., Marber, M., Salviati, L., Mougiakakos, D., Neuhuber, W., Sandri, M., Meisinger, C., and Hashemolhosseini, S. (2018). In mammalian skeletal muscle, phosphorylation of TOMM22 by protein kinase CSNK2/CK2 controls mitophagy. Autophagy 14, 311-335.


Matic, S., Muders, V., and Meisinger, C. (2018). Tuning the mitochondrial protein import machinery by reversible phosphorylation: from metabolic switches to cell cycle regulation. Curr. Opin. Physiol. 3, 49-56.


Carmona-Gutierrez, D., Bauer, M.A.,..Meisinger, C.,...Galluzi, L., Kroemer, G., and Madeo, F. (2018). Guidelines and recommendations on yeast cell death nomenclature. Microb. Cell 5, 4-31.


Taskin, A.A., Kücükköse, C., Burger, N., Mossmann, D., Meisinger, C.*, and Vögtle, F.N. (2017). The novel mitochondrial protease Ste23 is required for efficient presequence processing. Mol. Biol. Cell 28, 997-1002.     * corresp. author


Vögtle, F.N., Burkhart, J.M., Gonczarowska-Jorge, H., Kücükköse, C., Taskin, A.A., Kopczynski, D., Ahrends, R., Mossmann, D., Sickmann, A., Zahedi, R.P., and Meisinger, C. (2017). Landscape of submitochondrial protein distribution. Nat. Commun. 8, 290.


Meisinger, C., and Hunte, C. (2017). Editorial: Recent advances in mitochondrial biology - integrated aspects. Cell Tissue Res. 367, 1-3.


Krüger, V., Becker, T., Becker, L., Montilla-Martinez, M., Ellenrieder, L., Vögtle, F.N., Meyer, H.E., Ryan, M.T., Wiedemann, N., Warscheid, B., Pfanner, N., Wagner, R. and Meisinger, C. (2017). Identification of new channels by systematic analysis of the mitochondrial outer membrane. J. Cell Biol. 216, 3485-3495.


Ruf. S., Heberle, A.M., Langelaar-Makkinja, Gelino, S., Wilinson, D., Gerbeth, C., Schwarz, J.J., Holzwarth, B., Warscheid, B., Meisinger, C., van Vugt, M.A., Baumeister, R., Hansen, M., and Thediek, K. (2017). PLK1 (polo like kinase 1) inhibits MTOR complex 1 and promotes autophagy. Autophagy 13, 486-505.

Käser, S., Willemin, M., Schnarwiler, M., Schimanski, B., Poveda-Huertes, D., Oeljeklaus, S., Warscheid, B., Meisinger, C., and Schneider, A. (2017). Biogenesis of the mitochondrial DNA inheritance machinery in the mitochondrial outer membrane of Trypanosoma brucei. PLoS Pathog. 13, e1006808.

Ellenrieder, L., Opalinski, L., Becker, L., Krüger, V., Mirus, O., Straub, S.P., Ebell, K., Flinner, N., Stiller, S.B., Guiard, B., Meisinger, C., Wiedemann, N., Schleiff, E., Wagner, R., Pfanner, N., and Becker, T. (2016). Separating mitochondrial protein assembly and endoplasmic reticulum tethering by selective coupling of Mdm10. Nat. Commun. 7, 13021.

Eldomery,  M.K., Akdemir, Z.C., Vögtle, F.N., Charng, W.L., Mulica, P., Rosenfeld, J.A., Gambin, T., Gu, S., Burrage, L.C., Al Shamsi, A., Penney, S., Jhangiani, S.N., Zimmerman, H.H., Muzny, D.M., Wang, X., Tang, J., Medikonda, R., Ramachandran, P.V., Wong, L.J., Boerwinkle, E., Gibbs, R.A., Eng, C.M., Lalani, S.R., Hertecant, J., Rodenburg, R.J., Abdul-Rahman, O.A., Yang, Y., Xia, F., Wang, M.C., Lupski, J.R., Meisinger, C., and Sutton, V.R. (2016). MIPEP recessive variants cause a syndrome of left ventricular non-compaction, hyptonia and infantile death. Genome Med. 8, 106.

Mani, J., Meisinger, C., and Schneider, A. (2016). Peeping at TOMs-Diverse entry gates to mitochondria provide insights into the evolution of eukaryotes. Mol. Biol. Evol. 33, 337-351.

Lehmann, W., Mossmann, D., Kleemann, J., Mock, K., Meisinger, C., Brummer, T., Herr, R., Brabletz, S., Stemmler, M.P. and Brabletz, T. (2016). ZEB1 turns into a transcriptional activator by interacting with YAP1 in aggressive cancer types. Nat. Commun. 7, 10498.

Vögtle, F.N., Keller, M., Taskin, A.A., Horvath, S.E., Guan, X.L., Prinz, C., Opalinska, M., Zorzin, C., van der Laan, M., Wenk, M.R., Schubert, R., Wiedemann, N., Holzer, M., and Meisinger, C. (2015). The fusogenic lipid phosphatidic acid promotes the biogenesis of mitochondrial outer membrane protein Ugo1. J. Cell Biol. 210, 951-960.

Mani, J., Desy, S., Niemann, M., Chanfon, A., Oeljeklaus, S., Pusnki, M., Schmidt, O., Gerbeth, C., Meisinger, C., Warscheid, B., and Schneider, A. (2015). Discovery of novel mitochondrial protein import receptors in kinetoplastids – convergent evolution over large phylogenetic distances. Nat. Commun. 6, 6646.

Opalinska, M., and Meisinger, C. (2015). Metabolic control via the mitochondrial protein import machinery. Curr. Opin. Cell Biol. 33, 42-48.

Stroud, D.A., Maher, M.J., Lindau, C., Vögtle, F.N., Frazier, A.E., Surgenor, E., Mountford, H., Singh, A.P., Bonas, M., Oeljeklaus, S., Warscheid, B., Meisinger, C., Thorburn, D.R., and Ryan, M.T. (2015). COA6 is a mitochondrial complex IV assembly factor critical for biogenesis of mtDNA-encoded COX2. Hum. Mol. Genet. 24, 5404-5415.

Patterson, H.C., Gerbeth, C., Thiru, P., Vögtle, F.N., Knoll, M., Shahsafaei, A., Samocha, K.E., Huang, C.X., Harden, M.M., Song, R., Chen, C., Kao, J., Shi, J., Salmon, W., Shaul, Y.D., Stokes, M.P., Silva, J.C., Bell, G.W., MacArthur, D.G., Ruland, J., Meisinger, C., and Lodish, H.F. (2015). A respiratory chain controlled signal transduction cascade in the mitochondrial intermembrane space mediates H2O2 signaling. Proc. Natl. Acad. Sci. USA 112, E5679-5688.

Vögtle, F.N., and Meisinger, C. (2015). Mitochondriale Proteostase: (Patho)-physiologische Rolle von mitochondrialen Präsequenzproteasen. Biospektrum 3, 260-263.

Mossmann, D., Vögtle, F.N., Taskin, A.A., Teixeira, P.F., Ring, J., Burkhart, J.M., Burger, N., Pinho, C.M., Tadic, J., Loreth, D., Graff, C., Metzger, F., Sickmann, A., Kretz, O., Wiedemann, N., Zahedi, R.P., Madeo, F., Glaser, E., and Meisinger, C. (2014). Amyloid-beta peptide induces mitochondrial dysfunction by inhibition of preprotein maturation. Cell Metab.  20, 662-669.

Harbauer, A.B., Opalinska, M., Gerbeth, C., Herman, J.S., Rao, S., Schönfisch, B., Guiard, B., Schmidt, O., Pfanner, N., and Meisinger, C. (2014). Cell cycle-dependent regulation of mitochondrial preprotein translocase. Science 346, 1109-1113.

Heublein, M., Burgillos, M.A., Vögtle, F.N., Teixeira, P.F., Imhof, A., Meisinger, C., and Ott, M. (2014). The novel component Kgd4 recruits the E3 subunit to the mitochondrial alpha-ketoglutarate dehydrogenase. Mol. Biol. Cell 25, 3342-3349.

Harbauer, A.B., Zahedi, R.P., Sickmann, A., Pfanner, N., and Meisinger, C. (2014). The protein import machinery of mitochondria: A regulatory hub in metabolism, stress and disease. Cell Metab. 19, 357-372.

Schnarwiler, F., Niemann, M., Doiron, N., Harsman, A., Käser, S., Mani, J., Chanfon, A., Dewar, C.E., Oeljeklaus, S., Jackson, C.B., Pusnik, M., Schmidt, O., Meisinger, C., Hiller, S., Warscheid, B., Schnaufer, A.C., Ochsenreiter, T., and Schneider A. (2014). Trypanosomal TAC40 constitutes a novel subclass of mitochondrial beta-barrel proteins specialized in mitochondrial genome inheritance. Proc. Natl. Acad. Sci. U.S.A. 111, 7624-7629.

Opalinska, M., and Meisinger, C. (2014). Mitochondrial protein import under kinase surveillance. Microb. Cell 2, 51-57.

Yao, X., Dürr, U.H., Gattin, Z., Laukat, Y., Narayanan, R.L., Brückner, A.K., Meisinger, C., Lange, A., Becker, S., and Zweckstetter, M. (2014). NMR-based detection of hydrogen/deuterium exchange in liposome-embedded membrane proteins. PloS One 9, e112374.

Gerbeth, C., Schmidt, O., Rao, S., Harbauer, A.B., Mikropoulou, D., Opalinska, M., Guiard, B., Pfanner, N., and Meisinger, C. (2013). Differential regulation of the central mitochondrial import receptor by cytosolic and organelle-bound kinases. Cell Metab. 18, 578-587.

Niemann, M., Wiese, S., Mani, J., Chanfon, A., Jackson, C., Meisinger, C., Warscheid, B., and Schneider, A. (2013). Mitochondrial outer membrane proteome of Trypanosoma brucei reveals novel factors required to maintain mitochondrial morphology. Mol. Cell. Proteomics 12, 515-528.

Gerbeth, C., Mikropoulou, D., and Meisinger, C. (2013). From inventory to functional mechanisms: Regulation of the mitochondrial protein import machinery by phosphorylation. FEBS J. 280, 4933-4942.

Venne, A.S., Vögtle, F.N., Meisinger, C., Sickmann, A., and Zahedi, R.P. (2013). Novel highly sensitive, specific and straightforward strategy for comprehensive N-terminal proteomics reveals unknown substrates of the mitochondrial peptidase Icp55. J. Proteome Res. 12, 3823-3830.

Ieva, R., Heißwolf, A.K., Gebert, M., Vögtle, F.N., Wollweber, F., Mehnert, C.S., Oeljeklaus, S., Warscheid, B., Meisinger, C., van der Laan, M., and Pfanner, N. (2013). Mitochondrial inner membrane protease promotes assembly of presequence translocase by removing a carboxy-terminal targeting sequence. Nat. Commun. 4, 2853.

Büttner, S., Habernig, L., Broeskamp, F., Ruli, D., Vögtle, F.N., Vlachos, M., Macchi, F., Küttner, V., Carmona-Gutierrez, D., Eisenberg, T., Ring, J., Markaki, M., Taskin, A.A., Benke, S., Ruckenstuhl, C., Braun, R., Van den Haute, C., Bammens, T., van der Perren, A., Fröhlich, K.U., Winderickx, J., Kroemer, G., Baekelandt, V., Tavernarakis, N., Kovacs, G.G., Dengjel, J., Meisinger, C., Sigrist, S.J., and Madeo, F. (2013). Endonuclease G mediates -synuclein cytotoxicity during Parkinson's disease. EMBO J. 32, 3041-3054.

Rao, S., Schmidt, O., Harbauer, A.B., Schönfisch, B., Guiard, B., Pfanner, N., and Meisinger, C. (2012). Biogenesis of the preprotein translocase of the outer mitochondrial membrane: protein kinase A phosphorylates the precursos of Tom40 and impairs its import. Mol. Biol. Cell. 23,1618-1627.

Vögtle, F.N., Burkhart, J.M., Rao, S., Gerbeth, C., Hinrichs, J., Martinou, J.C., Chacinska, A., Sickmann, A., Zahedi, R.P., and Meisinger, C. (2012). Intermembrane space proteome of yeast mitochondria. Mol. Cell. Proteomics 11, 1840-1852.

Wilfing, F., Weber, A., Potthoff, S., Vögtle, F.N., Meisinger, C., Paschen, S.A., and Häcker, G. (2012). BH3-only proteins are tail-anchored in the outer mitochondrial membrane and can initiate the activation of Bax. Cell Death Differ. 19, 1328-1336.

Vucotic, M., Oeljeklaus, S., Wiese, S., Vögtle, F.N., Meisinger, C., Meyer, H.E., Zieseniss, A., Katschinski, D.M., Jans, D.C., Jakobs, S., Warscheid, B., Rehling, B., and Decker, M. (2012). Rcf1 mediates cytochrome oxidase assembly and respirasome formation, revealing heterogeneity of the enzyme complex. Cell Metab. 15, 336-347.

Harsman, A., Nieman, M., Pusnik, M., Schmidt, O., Burmann, B.M., Hiller, S., Meisinger, C., Schneider, A., and Wagner, R. (2012). Bacterial origin of a mitochondrial outer membrane protein translocase: New perspectives from comparative single channel electrophysiology. J. Biol. Chem. 287, 31437-31445.

Mossmann, D., Meisinger, C., Vögtle, F.N. (2012). Processing of mitochondrial presequences. Biochim. Biophys. Acta 1819, 1098-1106.     

Pusnik, M., Mani, J., Schmidt, O., Niemann, M., Oeljeklaus, S., Schnarwiler, F., Warscheid, B., Lithgow, B., Meisinger, C., and Schneider, A. (2012). An essential novel component of the non-canonical mitochondrial outer membrane protein import system of trypanosomatids. Mol. Biol. Cell 23, 3420-3428.

Horvath, S.E., Böttinger, L., Vögtle, F.N., Wiedemann, N., Meisinger, C., Becker, T., and Daum, G. (2012). Processing and topology of the yeast mitochondrial phosphatidyserine decarboxylase 1. J. Biol. Chem. 287, 36744-36755.

Vögtle, F.N., Prinz, C., Kellermann, J., Lottspeich, F., Pfanner, N., and Meisinger, C. (2011). Mitochondrial protein turnover: role of the precursor intermediate peptidase Oct1 in protein stabilization. Mol. Biol. Cell 22, 2135-2143

Schmidt, O., Harbauer, A.B., Rao, S., Eyrich, B., Zahedi, R.P., Stojanovski, D., Schönfisch, B., Guiard, B., Sickmann, A., Pfanner, N., and Meisinger, C. (2011). Regulation of mitochondrial protein import by cytosolic kinases. Cell 144, 227-239.

Becker, T., Wenz, L.S., Thornton, N., Stroud, D., Meisinger, C., Wiedemann, N., and Pfanner, N. (2011). Biogenesis of mitochondria: dual role of Tom7 in modulating assembly of the preprotein translocase of the outer membrane. J. Mol. Biol. 405, 113-124.

Vögtle, F.N., and Meisinger, C. (2012). Sensing mitochondrial homeostasis: the protein import machinery takes control. Dev. Cell 23, 234-236.

Alikhani, N., Berglund, A.K., Engmann, T., Spanning, E., Vögtle, F.N., Pavlov, P., Meisinger, C., Langer, T., and Glaser, E. (2011). Targeting capacity and conservation of PreP homologues localization in mitochondria of different species. J. Mol. Biol. 410, 400-410.

Pusnik, M., Schmidt, O., Perry, A.J., Oeljeklaus, S., Niemann, M., Warscheid, B., Lithgow, T., Meisinger, C., and Schneider, A. (2011). Mitochondrial Preprotein Translocase of Trypanosomatids Has a Bacterial Origin. Curr. Biol. 21, 1738-1743.

Kaiser, H.K., Surma, M.A., Mayer, F., Levental, I., Grzybek, M., Klemm, R.W., Da Cruz, S., Meisinger,C., Müller, V., Simons, K., and Lingwood, D. (2011). Molecular Convergence of bacterial and eukaryotic surface order. J. Biol. Chem. 286, 40631-40637.

Büttner, S., Ruli, D., Vögtle, F.N., Galluzzi, L., Moitzi, B., Eisenberg, T., Kepp, O., Habernig, L., Carmona-Gutierrez, D., Rockenfeller, P., Laun, P., Breitenbach, M., Khoury, C., Fröhlich, K.U., Rechberger, G., Meisinger, C., Kroemer,G. and Madeo, F. (2011). A yeast BH3 domain-containing protein mediates the mitochondrial pathway of apoptosis. EMBO J.  30, 2779-2792.

Becker, T., Wenz, L.S., Krüger, V., Lehmann, W., Müller, J.M., Goroncy, L., Zufall, N., Lithgow, T., Guiard, B., Chacinska, A., Wagner, R., Meisinger, C., and Pfanner, N. (2011). The mitochondrial import protein Mim1 promotes biogenesis of multispanning outer membrane proteins. J. Cell Biol. 194, 387-395.

Stroud, D.A., Becker, T., Qiu, J., Stojanovski, D., Pfannschmidt, S., Wirth, C., Hunte, C., Guiard, B., Meisinger, C., Pfanner, N., and Wiedemann, N. (2011). Biogenesis of mitochondrial beta-barrel proteins: the POTRA domain is involved in precursor release from the SAM complex. Mol. Biol. Cell 22, 2823-2833.

von der Malsburg, K., Müller, J.M., Maria Bohnert, M., Oeljeklaus, S., Kwiatkowska, P., Becker, T., Loniewska-Lwowska, A., Wiese, S., Rao, S., Milenkovic, D., Hutu, D.P., Zerbes, R.M., Schulze-Specking, A., Meyer, H.E., Martinou, J.C., Rospert, S., Rehling, P., Meisinger, C., Veenhuis, M., Warscheid, B., van der Klei, I.J., Pfanner, N., Chacinska, A., and van der Laan, M. (2011). Dual Role of Mitofilin in Mitochondrial Membrane Organization and Protein Biogenesis. Dev. Cell 21, 694-707.

Rao, S., Gerbeth, C., Harbauer, A., Mikropoulou, D., Meisinger, C., and Schmidt, O. (2011). Signaling at the gate: Phosphorylation of the mitochondrial protein import machinery. Cell Cycle 10, 2083-2090.

Chacinska, A., van der Laan, M., Mehnert, C.S., Guiard, B., Mick, D.U., Hutu, D.P., Truscott, K.N., Wiedemann, N., Meisinger, C., Pfanner, N., and Rehling, P. (2010). Distinct forms of mitochondrial TOM-TIM supercomplexes define signal-dependent states of preprotein sorting. Mol. Cell Biol. 30, 307-318.

Schmidt, O., Pfanner, N., and Meisinger, C. (2010). Mitochondrial protein import: from proteomics to functional mechanisms. Nature Rev. Mol. Cell. Biol. 11, 655-667.

Carmona-Gutierrez, D., Eisenberg, T., Büttner, S., Meisinger, C., Kroemer, G., and Madeo, F. (2010). Apoptosis in yeast: triggers, pathways, subroutines. Cell Death Differ. 17, 763-773.

Stroud, D.A., Meisinger, C., Pfanner, N., and Wiedemann, N. (2010). Assembling the outer membrane. Science 328, 831-832.

Harsman, A., Krüger, V., Bartsch, P., Honigmann, A., Schmidt, O., Rao, S., Meisinger, C., and Wagner, R. (2010). Protein conducting nanopores. J. Phys.: Condens. Matter 22, 454102.

Vögtle, F.N., Schmidt, O., Chacinska, A., Pfanner, N., and Meisinger, C. (2010). Native techniques for analysis of mitochondrial protein import. Meth. Mol. Biol. 619, 425-436.

Vögtle, F.N., Wortelkamp, S., Zahedi, R.P., Becker, D., Leidhold, C., Gevaert, K., Kellermann, J., Voos, W., Sickmann, A., Pfanner, N., and Meisinger, C. (2009). Global analysis of the mitochondrial N-Proteome identifies a processing peptidase critical for protein stability. Cell 139, 428-439.

Wiedemann, N., Meisinger, C., and Pfanner, N. (2009). Connecting organelles. Science 325, 403-403.

Gebert, N., Joshi, A.S., Kutik, S., Becker, T., McKenzie, M., Guan, X.L. Mooga, V.P., Stroud, D.A., Kulkarni, G., Wenk, M.R., Rehling, P., Meisinger, C., Ryan, M.T., Wiedemann, N., Greenberg, M.L., and Pfanner, N. (2009). Mitochondrial cardiolipin involved in outer-membrane protein biogenesis: implications for Barth syndrome. Curr. Biol. 19, 2133-2139.

Model, K., Meisinger, C., and Kühlbrandt, W. (2008). Cryo-EM structure of a yeast mitochondrial preprotein translocase. J. Mol. Biol. 383, 1049-1057.

Meisinger, C., Sickmann, A., and Pfanner, N. (2008). The mitochondrial proteome: from inventory to function. Cell 134, 22-24.

Becker, T., Vögtle, F.N., Stojanovski, D., and Meisinger, C. (2008). Sorting and assembly of mitochondrial outer membrane proteins. Biochim. Biophys. Acta 1777, 557-563.

Bolender, N., Sickmann, A., Wagner, R., Meisinger, C., and Pfanner, N. (2008). Multiple pathways for sorting mitochondrial precursor proteins. EMBO Rep. 9, 42-49.

Becker, T., Pfannschmidt, S., Guiard, B., Stojanovski, D., Milenkovic, D., Kutik, S., Pfanner, N., Meisinger, C., and Wiedemann, N. (2008). Biogenesis of the mitochondrial TOM complex: Mim1 promotes insertion and assembly of signal-anchored receptors. J. Biol. Chem. 283, 120-127.

Kutik, S., Stojanovski, D., Becker, L., Becker, T., Meinecke, M., Krüger, V., Prinz, C., Meisinger, C., Guiard, B., Wagner, R., Pfanner, N., and Wiedemann, N. (2008). Dissecting Membrane Insertion of Mitochondrial β-Barrel Proteins. Cell 132, 1011-1024.

Gabriel, K., Milenkovic, D., Chacinska, A., Müller, J., Guiard, B., Pfanner, N., and Meisinger, C. (2007). Novel mitochondrial intermembrane space proteins as substrates of the MIA import pathway. J. Mol. Biol. 365, 612-620.

Sanjuàn Szklarz, L.K., Kozjak-Pavlovic, V., Vögtle, F.N., Chacinska, A., Milenkovic, D., Vogel, S., Dürr, M., Westermann, B., Guiard, B., Martinou, J.C., Borner, C., Pfanner, N., and Meisinger, C. (2007). Preprotein transport machineries of yeast mitochondrial outer membranes are not required for Bax-induced release of intermembrane space proteins. J. Mol. Biol. 368, 44-54.

Meisinger, C., Pfannschmidt, S., Rissler, M., Milenkovic, D., Becker, T., Stojanovski, D., Youngman, M.J., Jensen, R.E., Chacinska, A., Guiard, B., Pfanner, N., and Wiedemann, N. (2007). The morphology proteins Mdm12/Mmm1 function in the major -barrel assembly pathway of mitochondria. EMBO J. 26, 2229-2239.

Reinders, J., Wagner, K., Zahedi, M.P., Stojanovski, D., Eyrich, B., van der Laan, M., Rehling, P., Sickmann, A., Pfanner, N., and Meisinger, C. (2007). Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase. Mol. Cell. Proteomics 6, 1896-1906.

Stojanovski, D., Guiard, B., Kozjak-Pavlovic, V., Pfanner, N., and Meisinger, C. (2007). Alternative role of the mitochondrial SAM complex in biogenesis of alpha-helical TOM proteins. J. Cell Biol. 179, 881-893.

Meisinger, C.*, Wiedemann, N.*, Rissler, M., Strub, A., Milenkovic, D., Schönfisch, B., Müller, H., Kozjak, V., and Pfanner, N. (2006). Mitochondrial protein sorting: differentiation of -barrel assembly by Tom7-mediated segregation of Mdm10. J. Biol. Chem. 281, 22819-22826.

Zahedi, R.P., Sickmann, A., Boehm, A.M., Winkler, C., Zufall, N., Schönfisch, B., Guiard, B., Pfanner, N., and Meisinger, C. (2006). Proteomic analysis of the yeast mitochondrial outer membrane reveals accumulation of a subclass of preproteins. Mol. Biol. Cell 17, 1436-1450.

Reinders, J., Zahedi, R.P., Pfanner, N., Meisinger, C., and Sickmann, A. (2006). Towards the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J. Proteome Res.  5, 1543-1554.

Stojanovski, D., Rissler, M., Pfanner, N., and Meisinger, C. (2006). Mitochondrial morphology and protein import – a tight connection? Biochim. Biophys. Acta 1763, 414-421.

Wiedemann, N., Urzica, E., Guiard, B., Müller, H., Lohaus, C., Meyer, H.E., Ryan, M.T., Meisinger, C., Mühlenhoff, U., Lill, R., and Pfanner, N. (2006). Mitochondrial desulfurase complex: essential role of Isd11 in iron-sulfur cluster synthesis on the Isu scaffold proteins. EMBO J. 25, 184-195.

Meisinger, C., Pfanner, N., and Truscott, K.N. (2006). Isolation of yeast mitochondria. Methods Mol. Biol. 313, 33-40.

Sanjuán Szklarz, L.K., Guiard, B., Rissler, M., Wiedemann, N., Kozjak, V., van der Laan, M., Lohaus, C., Marcus, K., Meyer, H.E., Chacinska, A., Pfanner, N., and Meisinger, C. (2005). Inactivation of the mitochondrial heat shock protein Zim17 leads to aggregation of matrix Hsp70s followed by pleiotropic effects on morphology and protein biogenesis. J. Mol. Biol. 351, 206-218.

Chacinska, A., Lind, M., Frazier, A.E., Dudek, J., Meisinger, C., Geissler, A., Sickmann, A., Meyer, H.E., Truscott, K.N., Guiard, B., Pfanner, N., and Rehling, P. (2005). Mitochondrial presequence translocase: switching between TOM tethering and motor recruitment involves Tim21 and Tim17. Cell 120, 817-829.

Becker, L., Bannwarth, M., Meisinger, C., Hill, K., Model, K., Krimmer, T., Casadio, R., Truscott, K.N., Schulz, G.E., Pfanner, N., and Wagner, R. (2005). Preprotein translocase of the outer mitochondrial membrane: reconstituted Tom40 forms a characteristic TOM pore. J. Mol. Biol. 353, 1011-1020.

van der Laan, M., Chacinska, A., Lind, M., Perschil, I., Sickmann, A., Meyer, H.E., Guiard, B., Meisinger, C., Pfanner, N., and Rehling, P. (2005). Pam17 is required for architecture and translocation activity of the mitochondrial protein import motor. Mol. Cell. Biol. 25, 7449-7458.

Zahedi, R.P., Meisinger, C., and Sickmann, A. (2005). Two-dimensional BAC/SDS PAGE for membrane proteomics. Proteomics 5, 3581-3588.

Brandner, K., Mick, D.U., Frazier, A.E., Meisinger, C., and Rehling, P. (2005). Taz1, an outer mitochondrial membrane protein, affects stability and assembly of inner membrane protein complexes – implications for Barth Syndrome. Mol. Biol. Cell 16, 5202-5214.

Meisinger, C., Rissler,  M., Chacinska, A., Milenkovic, D., Kozjak, V., Schönfisch, B., Lohaus, C., Meyer, H.E., Yaffe, M.P., Guiard,  B., Wiedemann, N., and Pfanner, N. (2004). The mitochondrial morphology protein Mdm10 functions in assembly of the preprotein translocase of the outer membrane. Dev.  Cell 7, 61-71.

Pfanner, N.*, Wiedemann, N., Meisinger, C.*, and Lithgow, T. (2004). Biogenesis of the mitochondrial outer membrane. Nature Struct. Mol. Biol. 11, 1044-1048.

Milenkovic, D., Kozjak, V., Wiedemann, N., Lohaus, C., Meyer, H.E., Guiard, B., Pfanner, N., and Meisinger, C. (2004). Sam35 of the mitochondrial protein sorting and assembly machinery is a peripheral outer membrane protein essential for cell viability. J. Biol. Chem. 279, 22781-22785.

Pfanner, N., Wiedemann, N., and Meisinger, C. (2004).  Double membrane fusion. Science 305, 1723-1724.

Wiedemann, N., Truscott, K.N., Pfannschmidt, S., Guiard, B., Meisinger, C., and Pfanner, N. (2004). Biogenesis of the protein import channel Tom40 of the mitochondrial outer membrane: intermembrane space components are involved in an early stage of the assembly pathway. J. Biol. Chem. 279, 18188-18194.

Chacinska, A., Pfannschmidt, S., Wiedemann, N., Kozjak, V., Sanjuan-Szklarz, L.K., Schulze-Specking, A., Truscott, K.N., Guiard, B., Meisinger, C., and Pfanner, N. (2004). Essential role of Mia40 in import and assembly of mitochondrial intermembrane space proteins. EMBO J. 23, 3735-3746.

Frazier, A., Dudek, J., Guiard, B., Voos, W., Li, Y., Lind, M., Meisinger, C., Geissler, A., Sickmann, A., Meyer, H.E., Bilanchone, V., Cumsky, M.G., Truscott, K.N., Pfanner, N., and Rehling, P. (2004). Pam16 plays an essential role in the mitochondrial protein import motor. Nature Struct. Mol. Biol. 11, 226-233.

Chacinska, A., Rehling, P., Guiard, B., Frazier A., Schulze-Specking, A., Pfanner, N., Voos, W. and Meisinger, C. (2003). Mitochondrial translocation contact sites: separation of dynamic and stabilizing elements in formation of a TOM-TIM-preprotein supercomplex. EMBO J. 22, 5370-5381.

Sickmann, A., Reinders, J., Wagner, Y., Joppich, C., Zahedi, R., Meyer, H.E., Schönfisch, B., Perschil, I., Chacinska, A., Guiard, B., Rehling, P., Pfanner, N. and Meisinger, C. (2003). The proteome of Saccharomyces cerevisiae mitochondria. Proc. Natl. Acad. Sci. USA 100, 13207-13212.

Wiedemann, N., Kozjak, V., Chacinska, A., Schönfisch, B., Rospert, S., Ryan, M.T., Pfanner, N., and Meisinger, C. (2003). Machinery for protein sorting and assembly in the mitochondrial outer membrane. Nature 424, 565-571.

Rehling, P., Pfanner, N., and Meisinger, C. (2003). Insertion of hydrophobic membrane proteins into the inner mitochondrial membrane – a guided tour. J. Mol. Biol. 326, 639-657. (Cover Figure)

Wiedemann, N., Kozjak, V., Prinz, T., Ryan, M.T., Dumont, M.E., Meisinger, C., Pfanner, N. and Truscott, K.N. (2003). Biogenesis of yeast mitochondrial cytochrome c: a unique relation to the TOM machinery. J. Mol. Biol. 327, 465-474.

Truscott, K.N., Voos, W., Frazier, A.E., Lind, M., Geissler, A., Müller, H., Sickmann, A., Meyer, H.E., Meisinger, C., Guiard, B., Rehling, P. and Pfanner, N. (2003). Presequence translocase associated import motor of mitochondria: an essential role of Pam18 in completion of protein translocation. J. Cell  Biol. 163, 707-713.

Rehling, P., and Meisinger, C. (2003). Proteintransport in Mitochondrien: TOM- und TIM-Komplexe. Biospektrum 9, 460-463.

Kozjak, V., Wiedemann, N., Milenkovic, D., Lohaus, C., Meyer, H.E., Guiard, B., Meisinger, C., and Pfanner, N. (2003). An essential role of Sam50 in the protein sorting and assembly machinery of the mitochondrial outer membrane. J. Biol. Chem. 278, 48520-48523.

Model, K., Prinz, T., Ruiz, T., Radermacher, M., Krimmer, T., Kühlbrandt, W., Pfanner, N., and Meisinger, C. (2002). Protein translocase of the outer mitochondrial membrane: role of import receptors in the structural organization of the TOM complex. J. Mol. Biol. 316, 657-666.

Chacinska, A., Pfanner, N., and Meisinger, C. (2002). How mitochondria import hydrophilic and hydrophobic proteins. Trends Cell Biol. 12, 299-303.

Geissler, A., Chacinska, A., Truscott, K.N., Wiedemann, N., Brandner, K., Sickmann, A., Meyer, H.E., Meisinger, C., Pfanner, N., and Rehling, P. (2002). The mitochondrial presequence translocase: an essential role of Tim50 in directing preproteins to the import channel. Cell 111, 507-518.

Truscott, K.N., Wiedemann, N., Rehling, P., Müller, H., Meisinger, C., Pfanner, N., and Guiard, B. (2002). Mitochondrial import of the ADP/ATP carrier: the essential TIM complex of the intermembrane space is required for precursor release from the TOM complex. Mol. Cell. Biol. 22, 7780-7789.

Meisinger, C., Ryan, M.T., Hill, K., Model, K., Hyun Lim, J., Sickmann, A., Müller, H., Meyer, H.E., Wagner, R., and Pfanner, N. (2001). The protein import channel of the outer mitochondrial membrane: a highly stable Tom40-Tom22 core structure differentially interacts with preproteins, small Tom proteins and import receptors. Mol. Cell. Biol. 21, 2337-2348.

Grothe, C., Meisinger, C., and Klaus, P. (2001). In vivo expression and localization of the fibroblast growth factor system in the intact and lesioned rat peripheral nerve and spinal ganglia.  J. Comp. Neurol. 434, 342-357.

Krimmer, T., Rapaport, D., Ryan, M.T., Meisinger, C., Kassenbrock, C.K., Blachly-Dyson, E., Forte, M., Douglas, M.G., Neupert, W., Nargang, F.E., and Pfanner, N. (2001). Biogenesis of porin of the outer mitochondrial membrane involves an import pathway via receptors and the general import pore of the TOM complex. J. Cell Biol. 152, 289-300.

Brix,  J., and Meisinger, C. (2001).  Handbuch zum Molekularbiologiekoffer für Schüler, Lehrer und Journalisten. Experimente zur modernen Molekularbiologie. Universität Freiburg.

Model, K., Meisinger, C., Prinz, T., Wiedemann, N., Truscott, K.N., Pfanner, N., and Ryan, M.T. (2001). Multi-step assembly of the protein import channel of the mitochondrial outer membrane. Nature Struct. Biol. 8, 361-370.

Meisinger, C., Sommer, T., and Pfanner, N. (2000). Purification of Saccharomcyes cerevisiae mitochondria devoid of microsomal and cytosolic contaminations. Anal. Biochem. 287, 339-342.

Grothe, C., Heese, K., Meisinger, C., Wewetzer, K., Kunz, D., Cattini, P., and Otten, U. (2000). Expression of interleukin-6 and its receptor in the sciatic nerve and cultured Schwann cells: relation to 18-kD fibroblast growth factor-2. Brain Res. 885, 172-181.

Van Wilpe, S., Ryan, M.T., Hill, K., Maarse, A.C., Meisinger, C., Brix, J., Dekker, P.J.T., Moczko, M., Wagner, R., Meijer, M., Guiard, B., Hönlinger, A., and Pfanner, N. (1999). TOM22 is a multifunctional organizer of the mitochondrial preprotein translocase. Nature 401, 485-489.

Meisinger, C., Brix, J., Model, K., Pfanner, N., and Ryan, M.T. (1999). The preprotein translocase of the outer mitochondrial membrane: receptors and a general import pore. Cell. Mol. Life Sci. 56, 817-824.6.

Klimaschewski, L., Meisinger, C., and Grothe, C. (1999). Localization and regulation of basic fibroblast growth factor and FGF-receptor 1 in rat superior cervical ganglion after axotomy. J. Neurobiol. 38, 499-506.

Grothe, C., Meisinger, C., Holzschuh, J., Wewetzer, K., and Cattini, P. (1998). Overexpression of the 18 kD and 21/23 kD fibroblast growth factor-2 isoforms in PC12 cells and Schwann cells results in altered cell morphology and growth. Mol. Brain Res. 57, 97-105.

Erck, C., Meisinger, C., Grothe, C., and Seidl, K. (1998). Regulation of nerve growth factor (NGF) and its low affinity receptor (p75) during myogenic differentiation. J. Cell. Physiol. 176, 22-31.

Grothe, C., Meisinger, C., and Wewetzer, K. (1998). Fibroblast growth factors. In M.Berry, A. Logan (eds.), CNS injuries. Cellular responses and pharmacological strategies. CRC Press, Boca Raton, New York, 201-218.

Meisinger, C., and Grothe, C. (1997). Differential regulation of FGF-2 and FGF receptor 1 mRNAs and FGF-2 isoforms in spinal ganglia and sciatic nerve after peripheral nerve lesion. J. Neurochem. 68, 1150-1158.

Meisinger, C., and Grothe, C. (1997). Expression of FGF-2 isoforms in the rat adrenal medulla during postnatal development in vivo. Brain Research 757, 291-294.

Grothe, C., and Meisinger, C. (1997). The multifunctionality of FGF-2 in the adrenal medulla.  Anat. Embryol. 195, 103-111.

Grothe, C., Meisinger, C., Hertenstein, A., Kurz, H., and Wewetzer, K. (1997). Expression of FGF-2 and FGF receptor 1 mRNAs in spinal ganglia and sciatic nerve: Regulation after peripheral nerve lesion. Neuroscience 76, 123-135.

Blottner, D., Stapf, C., Meisinger, C., and Grothe, C. (1997). Localization, differential expression and retrograde transport suggest physiological role of FGF-2 in spinal autonomic neurons of the rat. Eur. J. Neurosci. 9, 368-377.

Huber, K., Meisinger, C., and Grothe, C. (1997). Expression of FGF-2 in hypoglossal motoneurons stimulated by peripheral nerve injury.  J. Comp. Neurol. 382, 189-198.

Meisinger, C., Hertenstein, A. and Grothe, C. (1996). Fibroblast growth factor receptor 1 in the adrenal gland and PC12 cells: developmental expression and regulation by extrinsic molecules. Mol. Brain Res. 36, 70-78.

Meisinger, C., Zeschnigk, C., and Grothe, C. (1996). In vivo and in vitro effect of glucocorticoids on FGF-2 and FGF receptor 1 expression. J. Biol. Chem. 271, 16520-16525.

Meisinger, C., and Grothe, C. (1996). A sensitive RNase protection assay using 33P labeled antisense riboprobes. Mol. Biotechnol. 5, 289-291.

Grothe, C., and Meisinger, C. (1995). FGF-2 sense and antisense mRNA and FGF Receptor Type 1 mRNA are present in the embryonic and adult rat nervous system: specific detection by nuclease protection assay. Neurosci. Lett. 197, 175-178.