Meisinger lab
Mitochondrial signalling
We are interested in understanding how the mitochondrial proteome is assembled during biogenesis and how this process is regulated by cytosolic and mitochondrial signaling cascades. Additionally, we investigate how the composition and function of mitochondrial proteins can be adjusted to meet changing cellular demands. A crucial aspect of our research is examining how signal switches within the protein import machinery influence these processes in both health and disease.
Selected publications
Nat. Commun. 2024
DYRK1A signalling synchronizes the mitochondrial import pathways for metabolic rewiring
Marada A, Walter C, Suhm T, Shankar S, Nandy A, Brummer T, Dhaouadi I, Vögtle FN, Meisinger C
Nat. Commun. 2021
Global kinome profiling reveals DYRK1A as critical activator of the human mitochondrial import machinery
Walter C, Marada A, Suhm T, Ernsberger R, Muders V, Kücükköse C, Sánchez-Martín P, Hu Z, Aich A, Loroch S, Solari FA, Poveda-Huertes D, Schwierzok A, Pommerening H, Matic S, Brix J, Sickmann A, Kraft C, Dengjel J, Dennerlein S, Brummer T, Vögtle FN, Meisinger C
Mol. Cell 2020
An Early mtUPR: Redistribution of the Nuclear Transcription Factor Rox1 to Mitochondria Protects against Intramitochondrial Proteotoxic Aggregates
Poveda-Huertes D, Matic S, Marada A, Habernig L, Licheva M, Myketin L, Gilsbach R, Tosal-Castano S, Papinski D, Mulica P, Kretz O, Kücükköse C, Taskin AA, Hein L, Kraft C, Büttner S, Meisinger C, Vögtle FN
Nat Commun. 2017
Landscape of submitochondrial protein distribution
Vögtle FN, Burkhart JM, Gonczarowska-Jorge H, Kücükköse C, Taskin AA, Kopczynski D, Ahrends R, Mossmann D, Sickmann A, Zahedi RP, Meisinger C
Science 2014
Cell cycle-dependent regulation of mitochondrial preprotein translocase
Harbauer AB, Opalińska M, Gerbeth C, Herman JS, Rao S, Schönfisch B, Guiard B, Schmidt O, Pfanner N, Meisinger C
Cell Metab. 2014
Amyloid-β peptide induces mitochondrial dysfunction by inhibition of preprotein maturation
Mossmann D, Vögtle FN, Taskin AA, Teixeira PF, Ring J, Burkhart JM, Burger N, Pinho CM, Tadic J, Loreth D, Graff C, Metzger F, Sickmann A, Kretz O, Wiedemann N, Zahedi RP, Madeo F, Glaser E, Meisinger C
Cell Metab. 2013
Glucose-induced regulation of protein import receptor Tom22 by cytosolic and mitochondria-bound kinases
Gerbeth C, Schmidt O, Rao S, Harbauer AB, Mikropoulou D, Opalińska M, Guiard B, Pfanner N, Meisinger C
Cell 2011
Regulation of mitochondrial protein import by cytosolic kinases
Schmidt O, Harbauer AB, Rao S, Eyrich B, Zahedi RP, Stojanovski D, Schönfisch B, Guiard B, Sickmann A, Pfanner N, Meisinger C
Cell 2009
Global analysis of the mitochondrial N-proteome identifies a processing peptidase critical for protein stability
Vögtle FN, Wortelkamp S, Zahedi RP, Becker D, Leidhold C, Gevaert K, Kellermann J, Voos W, Sickmann A, Pfanner N, Meisinger C
Dev Cell. 2004
The mitochondrial morphology protein Mdm10 functions in assembly of the preprotein translocase of the outer membrane
Meisinger C, Rissler M, Chacinska A, Szklarz LK, Milenkovic D, Kozjak V, Schönfisch B, Lohaus C, Meyer HE, Yaffe MP, Guiard B, Wiedemann N, Pfanner N
Proc. Natl. Acad. Sci. USA 2003
The proteome of Saccharomyces cerevisiae mitochondria
Sickmann A, Reinders J, Wagner Y, Joppich C, Zahedi R, Meyer HE, Schönfisch B, Perschil I, Chacinska A, Guiard B, Rehling P, Pfanner N, Meisinger C
Nature 2003
Machinery for protein sorting and assembly in the mitochondrial outer membrane
Wiedemann N, Kozjak V, Chacinska A, Schönfisch B, Rospert S, Ryan MT, Pfanner N, Meisinger C
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